CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOACaptura de pantalla 2022 09 14 a las 10.27.10    

Functional organization of the mammalian genome

Research summary:

Copying and decoding the genomic information in a timely and accurate fashion is essential for life. Both tasks (DNA replication and transcription) are remarkably complex in scale and regulation, and the molecular machineries involved in them translocate on the same substrate, the chromatin. The general aim of our laboratory is understanding how the processes of DNA replication and transcription are coordinated in mammalian cells to maintain genome stability. This knowledge is fundamental for basic biology and have enormous implications for cell fate specification in physiology and pathology.

To investigate this we combine the application of genomics, epigenomics, epitranscriptomics, molecular biology and imaging techniques to a variety of cell scenarios with altered chromatin structure and/or transcription dysregulation.

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Some of the questions we try to address:

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If you are an enthusiastic scientists interested in investigating genome´s functionality and want to join our team, please send an updated cv and motivation letter to María Gómez (mgomez@cbm.csic.es).

Our lab participates in the Horizon Europe Marie Sklodowska-Curie Doctoral Network “RepliFate” (GA101072903)

www.replifate.eu

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* For external calls please dial 34 91196 followed by the extension number
Last nameNameLaboratoryExt.*e-mailProfessional category
Gallego JiménezAlicia4054469agallego(at)cbm.csic.esM2
García OrdóñezCarlos4054702Becario JAE Intro
Gómez VicentefranqueiraMaría4054724/4702mgomez(at)cbm.csic.esE.Científicos Titulares de Organismos Públicos de Investigación
Isoler AlcarazJavier4054702jisoler(at)cbm.csic.esTitulado Sup. Actividades Tecn. y Prof.GP1
La Iglesia MironesMiguel4054724/4702Estudiante
Martín VírgalaSara4054702sara.martin(at)cbm.csic.esM2 66,66%
Rus MorenoAdrián de4054702adrian.derus(at)cbm.csic.esM3 Predoc.formación
Segura MartínezJoana4054702joana.segura(at)cbm.csic.esTitulado Superior Grado de Doctor
Tong Ran4054724ran.tong(at)cbm.csic.esM3 Predoc.formación
Tur GraciaSara4054724/4702sara.tur(at)cbm.csic.esTitulado Sup. Actividades Tecn. y Prof.GP1

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Relevant publications:

  • Jodkowska K, Pancaldi V, Almeida R, Rigau M, Graña O, Fernández-Justel JM, Rodríguez-Acebes S, Rubio-Camarillo M, Carrillo-de Santa Pau E, Pisano D, Al-Sharour F, Valencia A, *Gómez M and *Méndez J. 2019. Three-dimensional connectivity and chromatin environment mediate the stochastic activation of stress-responsive DNA replication origins. BioRxiv 644971 doi:10.1101/644971 *CO-CORRESPONDING AUTHORS
  • Almeida, R., Fernández-Justel, J. M., Santa-María, C., Cadoret, J. C., Cano-Aroca, L., Lombraña, R., Herranz, G., Agresti, A. and Gómez, M. 2018. Chromatin conformation regulates the coordination between DNA replication and transcription. Nat Commun, 9:1590. PUBLICACIÓN RECOMENDADA EN FACULTY OF 1000
  • Lombraña, R., Álvarez, A., Fernández-Justel, J. M., Almeida, R., Poza-Carrión, C., Gomes, F., Calzada, A., Requena, J. M. and Gómez, M. 2016. Transcriptionally driven DNA replication programme of the human parasite Leishmania major. Cell Rep, 16: 1-13.
  • Lombraña, R., Almeida, R., Revuelta, I., Madeira, S., Herranz, G., Saiz, N., Bastolla, U. and Gómez, M. 2013. High-resolution analysis of DNA synthesis start sites and nucleosome architecture at efficient mammalian replication origins. EMBO J. 32: 2631-2644.

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