Friday, 6th December 2019

2017.03.01 lev18 mariano barbacid


Prof. Mariano Barbacid


Centro Nacional de Investigaciones Oncológicas (CNIO)

Galería de Imágenes






2017 02 17 Mariano Barbacid portminMariano Barbacid es Jefe del Grupo de Oncología Experimental del Centro Nacional de Investigaciones Oncológicas (CNIO). Realizó su Tesis Doctoral en el Centro de Investigaciones Biológicas (CSIC) bajo la dirección del Prof. David Vázquez. Desde 1974 a 1978 realizó una estancia postdoctoral en el National Cancer Institute (NCI) en Bethesda (Maryland, USA). En 1978 comenzó su propio grupo de investigación sobre la biología molecular de tumores humanos. Durante este tiempo realizó dos contribuciones de una gran importancia, el aislamiento en 1982 del primer gen del cáncer en humanos, H-RAS, y la identificación de la primera mutación asociada con el desarrollo del cáncer en humanos. En 1984 se trasladó al NCI-Fredrick en Maryland como Jefe de la Sección “Developmental Oncology” y en 1988 se trasladó al Bristol Myers-Squibb Pharmaceutical Research Institute en Princeton (New Jersey), donde fue Vice-Presidente de “Oncology Drug Discovery”.

En 1998 volvió a Madrid para crear y dirigir el CNIO. En 2011, después de 14 años, dejó la dirección del Centro para concentrarse en su propia investigación, cuyo foco es el diseño de nuevos animales modelo del cáncer y en la identificación y validación de dianas moleculares con valor terapéutico potencial. Su trabajo ha sido reconocido con numerosos premios y distinciones nacionales e internacionales. Entre otros, es miembro de EMBO, de la European Academy of Cancer Sciences, y desde 2012 es miembro extranjero de la US National Academy of Sciences.



Mariano Barbacid is Leader of the Spanish National Cancer Research Center (CNIO). He worked on the Ph.D. Thesis at the Centro de Investigaciones Biológicas (CSIC), under the direction of Prof. David Vázquez. From 1974 to 1978 he was trained as a postdoctoral fellow at the National Cancer Institute (NCI) in Bethesda (Maryland, USA). In 1978 he started his own group to work on the molecular biology of human tumors. His work led to the isolation in 1982 of the first human cancer gene, H-­‐RAS, and to the identification of the first mutation associated with the development of human cancer. In 1984 he moved to the NCI-­‐Frederick, in Maryland, as Head of the Department of the Developmental Oncology Section, and in 1988 he joined the Bristol Myers-­‐Squibb Pharmaceutical Research Institute in Princeton (New Jersey) where he became Vice-­‐President of Oncology Drug Discovery.

In 1998 he returned to Madrid to create and direct the CNIO. In 2011, after 14 years, he left the direction of the Center to concentrate on his own research that currently focuses on the design of new animal models of cancer and on the identification and validation of molecular targets with potential therapeutic value. His work has been recognized with numerous national and international prizes and distinctions. Among them, he is a Member of EMBO and the European Academy of Cancer Sciences. In 2012 he was elected a Foreign Member of the US National Academy of Sciences.


Publicaciones recientes / Recent publications:

  • Ambrogio C, Gómez-López G, Falcone M, Vidal A, Nadal E, Crosetto N, Blasco RB, Fernández­‐Marcos PJ, Sánchez­‐Céspedes M, Ren X, Wang Z, Ding K, Hidalgo M, Serrano M, Villanueva A, Santamaría D, Barbacid M. Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma. Nat Med. 2016 Mar;22(3):270-­7. doi:10.1038/nm.4041.
  • Drosten M, Simón-­Carrasco L, Hernández-Porras I, Lechuga CG, Blasco MT, Jacob HK, Fabbiano S, Potenza N, Bustelo XR, Guerra C, Barbacid M. H‐Ras and K­‐Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences. Cancer Res. 2016 Nov 21. doi: 10.1158/0008-­‐5472.CAN­‐16­‐2925.
  • Ambrogio C, Barbacid M, Santamaría D. In vivo oncogenic conflict triggered by co‐existing KRAS and EGFR activating mutations in lung adenocarcinoma. Oncogene. 2016 Oct 24. doi:10.1038/onc.2016.385.

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