Friday, 6th December 2019

2018.03.07 lev19 maria blasco


Prof. María Blasco


Centro Nacional de Investigaciones Oncológicas (CNIO)

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María A. Blasco es Directora del Centro Nacional de Investigaciones Oncológicas (CNIO). Realizó su Tesis Doctoral en el Centro de Biología Molecular "Severo Ochoa" bajo la dirección de la Profesora Margarita Salas. Desde 1993 a 1997 realizó una estancia postdoctoral en los laboratorios de Cold Spring Harbor en Nueva York bajo la dirección de la Dra. C.W. Greider. En 1997 regresó a España para iniciar su propio grupo de investigación en el Centro Nacional de Biotecnología en Madrid y en 2003 se trasladó al CNIO como Directora del Programa de Oncología Molecular y Jefa del Grupo de Telómeros y Telomerasa. En 2011 fue nombrada Directora del CNIO. María Blasco ha realizado contribuciones fundamentales que demuestran la importancia de los telómeros y de la telomerasa en cáncer y en envejecimiento. Su trabajo ha sido crucial en la demostración que el acortamiento telomérico es una de las principales rutas moleculares que conducen al envejecimiento y las enfermedades asociadas a la edad, incluido el cáncer. Su trabajo ha sido reconocido con numerosos premios y distinciones nacionales e internacionales. Entre otros, es Miembro de EMBO y ha recibido los Premios Josef Steiner Cancer Research, Rey Jaime I, Fundación Lilly, Santiago Ramón y Cajal y la Medalla de Oro de EMBO.



María A. Blasco is Director of the National Center of Oncological Research (CNIO). She worked on the Ph.D. Thesis at the Center of Molecular Biology “Severo Ochoa” under the direction of Prof. Margarita Salas. From 1993 to 1997 she was trained as a postdoctoral fellow at the Cold Spring Harbor Laboratories in New York under the direction of Dr. C.W. Greider. In 1997 she returned to Spain to start her own research group at the National Center of Biotechnology in Madrid and in 2003 she moved to the CNIO as Director of the Molecular Oncology Programme and Leader of the telomers and telomerase group. In 2011 she was appointed as CNIO Director. María Blasco has made fundamental contributions that show the importance of the telomers and the telomerase in cancer and aging. Her work has been crucial in the demonstration that telomeric shortening is one of the main molecular routes that led to aging and the diseases associated with age, including cancer. Her work has been recognized with numerous national and international prizes and distinctions. Among them, she is a Member of EMBO and has received the Prizes Josef Steiner Cancer Research, Rey Jaime I, Fundación Lilly, Santiago Ramón y Cajal and the Gold Medal of EMBO.


Publicaciones recientes / Recent publications:

  • Derevyanko A, Whittemore K, Schneider RP, Jiménez V, Bosch F, Blasco MA (2017). Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span. Aging Cell 16, 1353-1368.
  • Varela E, Muñoz-Lorente MA, Tejera AM, Ortega S, Blasco MA (2016). Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations. Nat Communications 7, 11739-
  • Bär C, Povedano JM, Serrano R, Benitez-Buelga C, Popkes M, Formentini I, Bobadilla M, Bosch F, Blasco MA (2016). Telomerase gene therapy rescues telomere length, bone marrow aplasia and survival in mice with aplastic anemia. Blood 127, 1770-1779.

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