Tuesday, 22nd January 2019

2017.12.01 francisco sanchez madrid

 

Prof. Francisco Sánchez Madrid

Servicio de Inmunología, Hospital Universitario de la Princesa,
Facultad de Medicina, Universidad Autónoma de Madrid
e Instituto de Investigación Sanitaria Princesa, Madrid, Spain

 

 

 

 

2017 12 01 Francisco Sanchez Madrid PortEl Prof. Francisco Sánchez Madrid es Jefe de Servicio de Inmunología del Hospital Universitario de la Princesa, Director Científico del Instituto de Investigación Sanitaria Princesa, Catedrático de Inmunología de la Facultad de Medicina de la Universidad Autónoma de Madrid y, sin duda, uno de los científicos españoles más prestigiosos. Mantiene desde hace más de 30 años una sólida y consolidada línea de investigación de gran originalidad, excelente producción científica y enorme relevancia biológica, centrada en los procesos de comunicación intercelular, adhesión, migración y polaridad leucocitaria, así como en la iniciación de la respuesta inmunitaria durante las interacciones entre linfocitos T y células presentadoras de antígeno. Más recientemente, el Prof. Sánchez Madrid ha centrado sus estudios en la importancia funcional de la comunicación intercelular y de la transferencia de información genética (mRNA y miRNA) horizontal a través de la sinapsis inmunológica.

En conjunto, la investigación del Prof. Sánchez Madrid ha contribuido de forma muy significativa al desarrollo de la Biomedicina en nuestro país y, en concreto, al avance del conocimiento de los mecanismos celulares y moleculares de las patologías inflamatorias y autoinmunes, como ejemplo paradigmático de investigación traslacional que ha dado lugar al desarrollo de nuevas terapias.

La trayectoria científica del Prof. Sánchez Madrid representa un claro ejemplo para todos de interés por la ciencia, entusiasmo, rigor científico y constancia, que se refleja en más de 400 publicaciones científicas internacionales, con numerosos artículos en revistas del máximo nivel, que han recibido más de 22.000 citaciones de otros autores, y con un Factor H de 77, por lo que es uno de los escasos científicos españoles incluido en la selecta lista internacional de investigadores más citados.

 


 

Prof. Francisco Sánchez­‐Madrid is Head of the Immunology Service of La Princesa University Hospital, Scientific Director of La Princesa Health Research Institute, Professor of Immunology at the Faculty of Medicine of the Universidad Autónoma de Madrid and, undoubtedly, one of the most prestigious Spanish scientists. For more than 30 years, he has maintained a solid and consolidated line of research of great originality, excellent scientific production and enormous biological relevance, focused on the intercellular communication, adhesion, migration and leukocyte polarity processes, as well as on the initiation of the immune response upon interactions between T lymphocytes and antigen­‐presenting cells. Most recently, Prof. Sánchez Madrid’s interest has focused on the functional relevance of the intercellular communication processes and the transference of genetic information (mRNA and miRNA) horizontally through the immunological synapse.

Collectively, Prof. Sánchez Madrid’s research has contributed significantly to the development of Biomedicine in our country and, particularly, to the advancement of our knowledge about the cellular and molecular mechanisms of inflammatory and autoimmune pathologies, as a paradigmatic example of translational research, which has led to the development of new therapies.

The scientific career of Prof. Sánchez­‐Madrid represents an example of enthusiasm, perseverance and genuine interest in science, which is reflected in more than 400 international scientific publications, with numerous articles in high impact journals that have received more than 22,000 citations, and with a H Factor of 77, making it one of the few Spanish scientists included in the select international list of most­‐cited researchers.

 

Publicaciones relevantes / Main publications:

  • Gutiérrez­‐Vázquez C, Rodríguez­‐Galán A, Fernández­‐Alfara M, Mittelbrunn M, Sánchez­‐Cabo F, Martínez­‐Herrera DJ, Ramírez­‐Huesca M, Pascual­‐Montano A, Sánchez-Madrid F. miRNA profiling during antigen-dependent T cell activation: A role for miR-­132­‐3p.Sci Rep. 2017 Jun 14;7(1):3508. doi: 10.1038/s41598­‐017-03689-7.
  • Bustos-Morán E, Blas-Rus N, Martin-­Cófreces NB, Sánchez-Madrid F. Microtubule-associated protein-4 controls nanovesicle dynamics and T cell activation. J Cell Sci. 2017 Apr 1;130(7):1217-­1223. doi: 10.1242/jcs.199042. Epub 2017 Feb 16.
  • Gutiérrez-­Vázquez C, Enright AJ, Rodríguez-Galán A, Pérez-García A, Collier P, Jones MR, Benes V, Mizgerd JP, Mittelbrunn M, Ramiro AR, Sánchez-Madrid F. 3' Uridylation controls mature microRNA turnover during CD4 T-­cell activation. RNA. 2017 Jun;23(6):882-­891. doi: 10.1261/rna.060095.116. Epub 201.
  • Villarroya-­Beltri C, Baixauli F, Mittelbrunn M, Fernández-Delgado I, Torralba D, Moreno-Gonzalo O, Baldanta S, Enrich C, Guerra S, Sánchez-Madrid F. ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins. Nat Commun. 2016 Nov 24;7:13588.
  • Cibrian D, Saiz ML, de la Fuente H, Sánchez-Díaz R, Moreno-Gonzalo O, Jorge I, Ferrarini A, Vázquez J, Punzón C, Fresno M, Vicente-Manzanares M, Daudén E, Fernández-Salguero PM, Martín P, Sánchez-Madrid F. CD69 controls the uptake of L-­tryptophan through LAT1-­CD98 and AhR-dependent secretion of IL-22 in psoriasis. Nat Immunol. 2016 Aug;17(8):985-­96. doi:10.1038/ni.3504.
  • Blas-­Rus N, Bustos-­Morán E, Pérez de Castro I, de Cárcer G, Borroto A, Camafeita E, Jorge I, Vázquez J, Alarcón B, Malumbres M, Martín-Cófreces NB, Sánchez-Madrid F. Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun. 2016 Apr 19;7:11389. doi: 10.1038/ncomms11389.
  • Barreiro O, Cibrian D, Clemente C, Alvarez D, Moreno V, Valiente Í, Bernad A, Vestweber D, Arroyo AG, Martín P, von Andrian UH, Sánchez Madrid F. Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair. Elife. 2016 Jun 15;5. pii: e15251. doi: 10.7554/eLife.15251.

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