Friday, 6th December 2019

2018.11.23 jorge lira ruas


Prof. Jorge Lira Ruas

Karolinska Institute
Stockholm, Sweden





2018 11 23 Jorge Lira Ruas MiniatureEl Dr. Jorge L. Ruas dirige su laboratorio sobre los aspectos moleculares de la fisiología del ejercicio físico en el Instituto Karolinska (Estocolmo, Suecia). El Dr. Ruas ha hecho trabajos fundamentales para entender los mecanismos moleculares que regulan los efectos beneficiosos que el ejercicio físico tiene en la salud. En este sentido, la investigación del Dr. Ruas se centra en entender cómo el músculo esquelético sedentario o adaptado a distintos programas de ejercicio se comunica con otros tejidos para ejercer su efecto sobre la salud. Para ello, utiliza un abordaje multidisciplinar que combina multitud de técnicas. Algunos ejemplos del resultado de su investigación son la identificación de mecanismos por los cuales el ejercicio físico protegen frente a la depresión nerviosa; o cómo el ejercicio físico puede contribuir a modular el sistema inmune y a controlar la aparición de enfermedades metabólicas como la resistencia a insulina y la diabetes de tipo 2. La excelencia y el impacto de su investigación vienen avaladas por la repercusión de sus publicaciones en revistas de alto nivel, así como por la concesión de premios otorgados por distintas instituciones.

El Dr. Ruas estudió Farmacia en la Universidad de Lisboa. Recibió su doctorado en el Instituto Karolinska, y a continuación llevó a cabo una etapa de investigación postdoctoral en el Instituto de Cáncer Dana-Farber, asociado a la Facultad de Medicina de la Universidad de Harvard (Boston, EEUU). Después de su formación postdoctoral, fue reclutado por el Instituto Karolinska para establecer su propio laboratorio en 2011.



Dr. Jorge L. Ruas leads his laboratory at the Karolinska Institute (Stockholm, Sweden), working on molecular aspects of physiology regulated by physical exercise. Dr. Ruas has carried out fundamental work to understand the molecular mechanisms that regulate the benefits that physical exercise imparts on human health. In this regard, the research of Dr. Ruas focuses on understanding how sedentary or exercised skeletal muscle crosstalks with other tissues and contributes to modulate healthy or pathological states. To this end, his laboratory applies a multi-disciplinary approach that combines the latest technologies. In this regard, and among many other achievements, Dr. Ruas's lab has identified some of the key molecular mechanisms that explain why physical exercise can be beneficial to prevent stress-induced depression, or how the exercise can contribute to improve metabolic homeostasis and fitness of the immune system. The relevance and impact of his research is illustrated by his outstanding publication record in some of the most prestigious scientific journals, and the awards that he has received in recognition of his excellence over the last few years since he started his own independent research programme.

Dr. Ruas received is degree in Pharmacy from University of Lisbon. He then received his PhD from the Karolinska Institute, and went on to pursue postdoctoral studies at the Dana-Farber Cancer Institute, affiliated to the Harvard Medical School (Boston, US). After his postdoctoral training, he was recruited to the Karolinska Institute to start up his own independent lab in 2011.


Publicaciones relevantes / Main publications:

  • Pettersson-Klein AT, Izadi M, Ferreira DMS, Cervenka I, Correia JC, Martinez-Redondo V, Southern M, Cameron M, Kamenecka T, Agudelo LZ, Porsmyr-Palmertz M, Martens U, Lundgren B, Otrocka M, Jenmalm-Jensen A, Griffin PR, Ruas JL. Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration. Mol. Metab. 2018. 9:28-42.
  • Agudelo LZ, Ferreira DMS, Cervenka I, Bryzgalova G, Dadvar S, Jannig PR, Pettersson-Klein AT, Lakshmikanth T, Sustarsic EG, Porsmyr-Palmertz M, Correia JC, Izadi M, Martínez-Redondo V, Ueland PM, Midttun Ø, Gerhart-Hines Z, Brodin P, Pereira T, Berggren P-O, and Ruas JL. Kynurenic acid and GPR35 regulate adipose tissue energy homeostasis and inflammation. Cell Metab. 2018 Feb 6;27(2):378-392.
  • Mills R, Taylor-Weiner H, Correia JC, Agudelo LZ, Allodi I, Kolonelou C, Martinez-Redondo V, Ferreira DMS, Nichterwitz DMS, Comley LH, Lundin V, Hedlund E, Ruas JL#, Teixeira AI#. Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation. Mol. Metab. 2017 Nov 7. Epub ahead of print. # Co-corresponding authors
  • Cervenka I, Agudelo LZ, and Ruas JL. Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health. Science. 2017 Jul 28;357(6349).
  • Martinez-Redondo V, Jannig PR, Correia JC, Ferreira DM, Cervenka I, Lindvall JM, Sinha I, Izadi M, Pettersson-Klein AT, Agudelo LZ, Gimenez-Cassina A, Brum PC, Dahlman-Wright K, Ruas JL. Peroxisome proliferator-activated receptor gamma coactivator-1alpha isoforms selectively regulate multiple splicing events on target genes. J. Biol. Chem. 2016 Jul 15;291(29):15169-84. PMID: 27231350.
  • Correia JC, Massart J, de BoerJF, Porsmyr-Palmertz M, Martínez-Redondo V, Agudelo LZ, Sinha I, Meierhofer D, Ribeiro V, Björnholm M, Sauer S, Dahlman-Wright K, Zierath JR, Groen AK, and Ruas JL. Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism. Mol. Metab. 2015. Dec; 4(12):891-902.
  • Agudelo LZ, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson A, Ferreira DMS, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, and Ruas JL. Skeletal Muscle PGC-1α Modulates Kynurenine Metabolism and Mediates Resilience to Stress-induced Depression. Cell. 2014 Sep 25; 159(1): 33-45.
  • Ruas, JL#, White, JP, Brannan, KT, Harrison, BC, Greene, NP, Wu, J, Kleiner, S, Estall, JL, Irving, BA, Lanza, IR, Rasbach, KA, Okutsu, M, Nair, KS, Yan, Z, Leinwand, LA, and Spiegelman, BM#. A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 2012 Dec 7; 151(6): 1319-1331. # Co-corresponding authors

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