Cabecera 2019 CBMSO CSIC UAM

Wednesday, 17th July 2019

Marie Skłodowska-Curie PhD position at the Laboratory of Human Neural Stem Cells

Open position for: Marie Skłodowska-Curie PhD position at the Laboratory of Human Neural Stem Cells (Center of Molecular Biology “Severo Ochoa” and Autonomous University of Madrid).

Title: Improving integration and connectivity of Dopaminergic neurons in vivo.

Contract: PhD scholarship at the Laboratory of Human Neural Stem Cells, Department of Molecular Neuropathology (Center of Molecular Biology “Severo Ochoa”, CBMSO), and Department of Molecular Biology (Autonomous University of Madrid, UAM). Start date: during the second half of September 2019.

Closing date for receipt of applications: August 1, 2019.

Job Summary: Applications are invited from suitably qualified candidates for a position funded by the Marie Skłodowska-Curie project “ASCTN-Training” within the Horizon 2020 Programme of the European Union, starting latest September 30, 2019. The appointment will be on a temporary basis for a maximum period of 3 years (PhD student) and will be placed at the Department of Molecular Neuropathology (Center of Molecular Biology “Severo Ochoa”, CBMSO), and Department of Molecular Biology (Autonomous University of Madrid, UAM) (Madrid, Spain).

ASCTN-Training is a four-year project, funded by the European Union Horizon 2020 Programme (H2020-MSCA-ITN-2018) under the Marie Skłodowska-Curie Innovative Training Network and Grant Agreement No. 813851. ASCTN-Training is addressing existing gaps within Human Stem Cell-based Neuronal disorders (NDs) Modelling (NDM) for research to develop new medicines for the treatment of neurological disorders (e.g. Parkinson´s (PD), Huntington´s (HD) and Demyelination’s (DM) diseases), which occur as a result of acute or progressive loss of cells, glial or neuronal, and structures and function in the brain. ASCTN-Training sets out with the ambition to educate and train students within and across different scientific disciplines: biotechnology (Human Pluripotent Stem Cells (hPSCs) neuronal and glial differentiation using brain-on-chip technology and microfluidics, 3D tissue engineering/cerebral organoids and nano-engineering of culture conditions), molecular biology (Ex vivo gene expression, Direct cellular reprograming, mouse genetic modification, single cell analysis), In vivo mouse manipulations (Animal models of NDs, stem cell transplants into the brain, scaffold implantation, direct tissue engineering).

The intended PhD student will be a member of a multi-disciplinary team and will be responsible for improving the integration and connectivity of grafted DA neurons in mouse brains by: 1) Identifying surface markers (from single cell RNAseq data) for the isolation of specific subpopulations of DA progenitors/precursors suitable for transplantation. 2) Analyzing in vivo short-term performance of pre-differentiated DAergic neurons; survival, differentiation & integration. 3) Analyzing if transplanted cells reproduce SN-striatal connectivity using TVA and rabies glycoprotein technology, by animal behaviour, neurotracers and electrophysiology. 4) Develop transplantable conductive scaffolds (in vivo 3D printing) than can help to regenerate connectivity of the transplanted DAergic neurons with the host neural circuits.

A summary of the thesis project, and full details of the offer can be made available upon request, at This email address is being protected from spambots. You need JavaScript enabled to view it., and also can be found at Euraxess web site.


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