Wednesday, 29th June 2016
17th Severo Ochoa Seminar Cycle 01/07/2016
Prof. Fiona M. Watt: Regulation of epidermal stem cell fate
Margarita Salas ha sido galardonada con la Medalla Echegaray concedida por la Real Academia de Ciencias Exactas, Físicas y Naturales
Descubierta una proteína que "debilita" la barrera interna de los vasos sanguíneos durante la inflamación
CBMSO announces its participation in the European project METAFLUIDICS
Last March 16th, Dr Manuel Serrano gave the XVII commemorative "Eladio Viñuela" lesson at the CBMSO. The ceremony was presided by Carmen Vela (I+D+I State secretary), Rafael Garesse (Research and innovation Vice chancellor of UAM), Margarita Salas (President of the "Severo Ochoa" Foundation), Cesar de Haro (Director of the "Eladio Viñuela" Institute) and Jose F. de Celis (CBMSO Director)
Convenio de colaboración entre el CBMSO y la Fundación SEUR para promover el proyecto TAPONES PARA UNA NUEVA VIDA
ENDOCORNEA. Convenio de Colaboración entre el Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz y el CSIC para investigar en el CBMSO la respuesta inflamatoria del endotelio de córnea humana y su relación con patologías oculares
Convenio de colaboración entre la Fundación Severo Ochoa y la Fundación Isabel Gemio para promover la investigación de enfermedades metabólicas hereditarias
Consolider BrainAge 2010
Brain dysfunction during aging
Aims to explore question is whether developmental mechanisms can help to maintain adult organ homeostasis and their relationship with disease
Ultrahigh-throughput platform for the screening of thermostable proteins by thermophillic in vitro transcription-translation and microfluidics
A new human primase/polymerase with a potential impact in aging
Redes moleculares y celulares en enfermedades inflamatorias
Host Microbe Interactions in Health and Disease: Interface with the Immune System
Study of cellular and molecular mediators of fibrogenesis
European Consortium for Development of Stem Cell-Based Therapy for Thymic Regeneration
The study of the biology of neural stem cells for its use in cell therapy of neurodegenerative diseases
Spanish cell therapy network



At the CBMSO we canalize our research to understand the molecular basis of human pathologies in particular of age-related diseases, most prevalent in our society, with the final aim to provide the necessary knowledge for the design of efficient therapies that help improve overall health and life expectancy.

Our strategic lines are based on two realities:

  • a societal need to reduce the impact of the most invalidating diseases,
  • the current involvement of the CBMSO in the study of the molecular mechanisms of pathologies with increased incidence in the aged.


Taking advantage of our current workforce, the CBMSO strategic plan aims at improving the efficiency of our research and its outreach by nucleating the Center´s research focus on the molecular basis of human diseases with special emphasis on those pathologies associated with age including brain degenerative disorders, immune and inflammatory components of different diseases, and disturbances in the control of cell proliferation and differentiation.


  • strengthen interactions between the basic research teams at the CBMSO and clinical researchers working in associated clinical institutes and hospitals.
  • disseminate information about the causes and underlying molecular mechanisms of age-related diseases and advances in pathological aging research to the general public, health care professionals and the scientific community.
  • boost already exiting intramural interactions between genetic, structural, biological and behavioural approaches to research on the molecular basis of disease and disease-associated events that disturb the normal aging process.
  • provide new research resources, both through the incorporation of new research groups and cutting-edge infrastructure.

Featured News

Científicos españoles descubren en cerebros de pacientes de Alzheimer que estaban infectados por hongos de su propia flora
  • Novedades en la investigación sobre el Alzheimer. El hallazgo puede ofrecer claves para entender mejor el origen de este tipo de demencias.

Representative Publications

Recent Publications

pdf flat small Fear-of-intimacy mediated zinc transport controls the function of Zn-finger transcription factors involved in myogenesis

pdf flat small RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border

pdf flat small Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons

pdf flat small Structure of developmental gene regulatory networks from the perspective of cell fate-determining genes

pdf flat small Resequencing and assembly of seven complex loci to improve the Leishmania major (Friedlin strain) reference genome

pdf flat small Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression

pdf flat small Gene transfer of brain derived neurotrophic factor (BDNF) prevents neurodegeneration triggered by frataxin deficiency

pdf flat small Gene transfer of brain derived neurotrophic factor (BDNF) prevents neurodegeneration triggered by frataxin deficiency

pdf flat small Cellular Barriers after Extravasation: Leukocyte Interactions with Polarized Epithelia in the Inflamed Tissue

pdf flat small PTEN recruitment controls synaptic and cognitive function in Alzheimer's models

pdf flat small MEPSA: minimum energy pathway analysis for energy landscapes

pdf flat small Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina

pdf flat small Resistance of Hepatitis C Virus to Inhibitors: Complexity and Clinical Implications

pdf flat small NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation

pdf flat small Establishment of a Developmental Compartment Requires Interactions between Three Synergistic Cis-regulatory Modules

pdf flat small Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2

pdf flat small Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection

pdf flat small Bacteriophage GIL01 gp7 interacts with host LexA repressor to enhance DNA binding and inhibit RecA-mediated auto-cleavage

pdf flat small Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction

pdf flat small ERAP1 polymorphism relevant to inflammatory disease shapes the peptidome of the birdshot chorioretinopathy-associated HLA-A*29:02 antigen

pdf flat small Cell competition, apoptosis and tumour development

pdf flat small Essential role for polymerase specialization in cellular nonhomologous end joining

pdf flat small The Homeodomain Iroquois Proteins Control Cell Cycle Progression and Regulate the Size of Developmental Fields

pdf flat small The Spalt Transcription Factors Generate the Transcriptional Landscape of the Drosophila melanogaster Wing Pouch Central Region

pdf flat small The study of the Bithorax-complex genes in patterning CCAP neurons reveals a temporal control of neuronal differentiation by Abd-B

pdf flat small miR-9-5p suppresses pro-fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2

pdf flat small Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection

pdf flat small T-cell intracellular antigens in health and disease

pdf flat small Multifunctionality of a Picornavirus Polymerase Domain: Nuclear Localization Signal and Nucleotide Recognition

pdf flat small The Mammalian Cell Cycle Regulates Parvovirus Nuclear Capsid Assembly

pdf flat small Biodiversity and distribution of polar freshwater DNA viruses

pdf flat small Chromatin and development: a special issue


Scientific Report


Nicolás Cabrera, 1, 28049 Madrid
Tel.: +34-911964401
Fax: +34-911964420
institucional at