Wednesday, 2nd September 2015
Hedgehog Signaling in Development, Tissue repair and Cancer
October 21-25, 2015, Puerto Varas, Chile
Tribute to Alfredo Villasante
Consolider BrainAge 2010
Brain dysfunction during aging
Aims to explore question is whether developmental mechanisms can help to maintain adult organ homeostasis and their relationship with disease
Ultrahigh-throughput platform for the screening of thermostable proteins by thermophillic in vitro transcription-translation and microfluidics
La mitocondria y su implicación en patología humana
A new human primase/polymerase with a potential impact in aging
Redes moleculares y celulares en enfermedades inflamatorias
Host Microbe Interactions in Health and Disease: Interface with the Immune System
Study of cellular and molecular mediators of fibrogenesis
European Consortium for Development of Stem Cell-Based Therapy for Thymic Regeneration
The study of the biology of neural stem cells for its use in cell therapy of neurodegenerative diseases
Spanish cell therapy network



At the CBMSO we canalize our research to understand the molecular basis of human pathologies in particular of age-related diseases, most prevalent in our society, with the final aim to provide the necessary knowledge for the design of efficient therapies that help improve overall health and life expectancy.

Our strategic lines are based on two realities:

  • a societal need to reduce the impact of the most invalidating diseases,
  • the current involvement of the CBMSO in the study of the molecular mechanisms of pathologies with increased incidence in the aged.


Taking advantage of our current workforce, the CBMSO strategic plan aims at improving the efficiency of our research and its outreach by nucleating the Center´s research focus on the molecular basis of human diseases with special emphasis on those pathologies associated with age including brain degenerative disorders, immune and inflammatory components of different diseases, and disturbances in the control of cell proliferation and differentiation.


  • strengthen interactions between the basic research teams at the CBMSO and clinical researchers working in associated clinical institutes and hospitals.
  • disseminate information about the causes and underlying molecular mechanisms of age-related diseases and advances in pathological aging research to the general public, health care professionals and the scientific community.
  • boost already exiting intramural interactions between genetic, structural, biological and behavioural approaches to research on the molecular basis of disease and disease-associated events that disturb the normal aging process.
  • provide new research resources, both through the incorporation of new research groups and cutting-edge infrastructure.

View our latest work

Un 'interruptor' regula el intercambio de genes entre bacterias
  • Descrito el mecanismo responsable de que los genes de transferencia de la bacteria Gram-positiva 'Bacillus subtilis' estén regulados de forma precisa
  • El trabajo liderado por el CSIC podría ser la base para desarrollar herramientas biotecnológicas y sistemas con implicaciones clínicas e industriales

Representative Publications

pdf flat small 4-Hydroxynonenal induces Nrf2-mediated UCP3 upregulation in mouse cardiomyocytes

pdf flat small Maximum-Likelihood Phylogenetic Inference with Selection on Protein Folding Stability

pdf flat small Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair

pdf flat small Biodiversity and distribution of polar freshwater DNA viruses

pdf flat small Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease

pdf flat small Local RNA flexibility perturbation of the IRES element induced by a novel ligand inhibits viral RNA translation

pdf flat small Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase

pdf flat small Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders

pdf flat small The Mammalian Cell Cycle Regulates Parvovirus Nuclear Capsid Assembly

pdf flat small The Effects of PMM2-CDG-Causing Mutations on the Folding, Activity, and Stability of the PMM2 Protein

Recent Publications

pdf flat small miR-9-5p suppresses pro-fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2

pdf flat small Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection

pdf flat small T-cell intracellular antigens in health and disease

pdf flat small Multifunctionality of a Picornavirus Polymerase Domain: Nuclear Localization Signal and Nucleotide Recognition

pdf flat small The Mammalian Cell Cycle Regulates Parvovirus Nuclear Capsid Assembly

pdf flat small Biodiversity and distribution of polar freshwater DNA viruses

pdf flat small Chromatin and development: a special issue


Discover our groups

Bacterial morphogenesis

Scientific Report


Nicolás Cabrera, 1, 28049 Madrid
Tel.: +34-911964401
Fax: +34-911964420
institucional at