Monday, 23rd April 2018
Advances in Biomedicine Seminar Cycle 20/04/2018
Jan Roelof van der Meer: Molecular and Ecological Adaptations in a Model Pseudomonas Integrative and Conjugative Element
Advances in Biomedicine Seminar Cycle 27/04/2018
Beatriz Rico: Building cortical networks: from molecules to function
19th Severo Ochoa Seminar Cycle 04/05/2018
Jean Sébastien Hoffmann: Adaptive mechanisms to replicate stress: implication for cancer prognosis and resistance
19th Severo Ochoa Seminar Cycle 11/05/2018
Andreas Lüthi: Ensemble coding of behavior in amygdala circuits
19th Severo Ochoa Seminar Cycle 01/06/2018
Franz Ulrich Hartl: Molecular chaperone functions in protein folding and quality control
19th Severo Ochoa Seminar Cycle 15/06/2018
Renato Paro: An intrinsic tumour eviction mechanism in Drosophila
The CBMSO joins the celebration of International Women's and Girls' Day in Science. The CBMSO has a staff of 696 workers, of which 407 are women
La Academia de Ciencias premia a Margarita Salas con la Medalla Echegaray
Agreement between the Spanish Niemann Pick Foundation and the Severo Ochoa Foundation to support research on Niemann Pick disease in the group of Dr. Lola Ledesma
Convenio entre RedELA, Red de enfermos de esclerosis lateral amiotrófica (ELA), la Fundación Severo Ochoa y el grupo de investigación del Dr. Luis Carrasco para continuar con el estudio sobre la etiología de la ELA
Ginés Morata, Foreign Member of the Royal Society of London
Convenio de colaboración entre el Instituto de Investigación Sanitaria Fundación Jiménez Díaz y la Fundación Severo Ochoa para realizar el proyecto “Endocórnea 2”
An H2020-MSCA-Innovative Training Network for 10 PhD students with research projects aimed at improving immune receptor function for their use in immunotherapy against cancer (H2020-MSCA-ITN GA 721358)
European Training Network for cell-based Regenerative Medicine
CBMSO announces its participation in the European project METAFLUIDICS
Convenio de colaboración entre el CBMSO y la Fundación SEUR para promover el proyecto TAPONES PARA UNA NUEVA VIDA
Short videos
Answers to eight essential questions about our cells
Convenio de colaboración entre la Fundación Severo Ochoa y la Fundación Isabel Gemio para promover la investigación de enfermedades metabólicas hereditarias
Ultrahigh-throughput platform for the screening of thermostable proteins by thermophillic in vitro transcription-translation and microfluidics
A new human primase/polymerase with a potential impact in aging
Host Microbe Interactions in Health and Disease: Interface with the Immune System
Spanish cell therapy network



In the CBMSO we focus our research on the study of the molecular basis of human diseases with the ultimate goal of providing the necessary knowledge to design therapies, procedures and diagnostic methods that help improve the quality and life expectancy.

Our research in molecular biomedicine is based on two realities:

  • the need to reduce the social impact of the most disabling diseases.
  • the need to understand the molecular mechanisms of diseases to be able to translate them into biomedical applications.

Featured News

Brain-derived neurotrophic factor (BDNF) prevents neurodegeneration caused by frataxin deficiency
  • A study just published in the journal Molecular Therapy demonstrates that the neurotrophic factor BDNF is able to prevent the degeneration of neurons caused by frataxin deficiency (which is responsible for the development of Friedreich's ataxia)
  • Although it is a work of basic research with an animal model, this study suggests potential new avenues for therapeutic intervention into Friedreich's ataxia

Representative Publications

Recent Publications

pdf flat small The Zn-finger domain of human PrimPol is required to stabilize the initiating nucleotide during DNA priming

pdf flat small Regulatory Lymphoid and Myeloid Cells Determine the Cardiac Immunopathogenesis of Trypanosoma cruzi Infection

pdf flat small L-arginine supplementation reduces mortality and improves disease outcome in mice infected with Trypanosoma cruzi

pdf flat small Genome Sequence of Trypanosoma cruzi Strain Bug2148

pdf flat small A Disulfide Bond in the Membrane Protein IgaA Is Essential for Repression of the RcsCDB System

pdf flat small A Specialized Peptidoglycan Synthase Promotes Salmonella Cell Division inside Host Cells

pdf flat small Phaeocystis globosa Virus DNA Polymerase X: a “Swiss Army knife”, Multifunctional DNA polymerase-lyase-ligase for Base Excision Repair

pdf flat small The anti/syn conformation of 8-oxo-7,8-dihydro-2′-deoxyguanosine is modulated by Bacillus subtilis PolX active site residues His255 and Asn263. Efficient processing of damaged 3′-ends

pdf flat small Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches

pdf flat small A bead-assisted flow cytometry method for the semi-quantitative analysis of Extracellular Vesicles

pdf flat small CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels

pdf flat small A multi-parametric analysis of Trypanosoma cruzi infection: common pathophysiologic patterns beyond extreme heterogeneity of host responses

pdf flat small T-Cell Intracellular Antigens and Hu Antigen R Antagonistically Modulate Mitochondrial Activity and Dynamics by Regulating Optic Atrophy 1 Gene Expression

pdf flat small Two-step ATP-driven opening of cohesin head

pdf flat small Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis

pdf flat small Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development

pdf flat small Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival

pdf flat small Human PrimPol activity is enhanced by RPA

pdf flat small Mutualism supports biodiversity when the direct competition is weak

pdf flat small Discovery of a new family of relaxases in Firmicutes bacteria


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