Tuesday, 21st April 2015
16th Severo Ochoa Seminar Cycle 24/04/2015
Prof. Jürg Bähler: Quantitative analysis of fission yeast transcriptomes and proteomes
Cellular synapsis for cell-cell signalling
Workshop 26 - 29 May 2015, San Lorenzo de El Escorial (Madrid), Spain
Hedgehog Signaling in Development, Tissue repair and Cancer
October 21-25, 2015, Puerto Varas, Chile
21th Severo Ochoa Memorial Lecture
21th Severo Ochoa Memorial Lecture Video
Consolider BrainAge 2010
Brain dysfunction during aging
Aims to explore question is whether developmental mechanisms can help to maintain adult organ homeostasis and their relationship with disease
Ultrahigh-throughput platform for the screening of thermostable proteins by thermophillic in vitro transcription-translation and microfluidics
La mitocondria y su implicación en patología humana
A new human primase/polymerase with a potential impact in aging
Redes moleculares y celulares en enfermedades inflamatorias
Host Microbe Interactions in Health and Disease: Interface with the Immune System
Study of cellular and molecular mediators of fibrogenesis
European Consortium for Development of Stem Cell-Based Therapy for Thymic Regeneration



At the CBMSO we canalize our research to understand the molecular basis of human pathologies in particular of age-related diseases, most prevalent in our society, with the final aim to provide the necessary knowledge for the design of efficient therapies that help improve overall health and life expectancy.

Our strategic lines are based on two realities:

  • a societal need to reduce the impact of the most invalidating diseases,
  • the current involvement of the CBMSO in the study of the molecular mechanisms of pathologies with increased incidence in the aged.


Taking advantage of our current workforce, the CBMSO strategic plan aims at improving the efficiency of our research and its outreach by nucleating the Center´s research focus on the molecular basis of human diseases with special emphasis on those pathologies associated with age including brain degenerative disorders, immune and inflammatory components of different diseases, and disturbances in the control of cell proliferation and differentiation.


  • strengthen interactions between the basic research teams at the CBMSO and clinical researchers working in associated clinical institutes and hospitals.
  • disseminate information about the causes and underlying molecular mechanisms of age-related diseases and advances in pathological aging research to the general public, health care professionals and the scientific community.
  • boost already exiting intramural interactions between genetic, structural, biological and behavioural approaches to research on the molecular basis of disease and disease-associated events that disturb the normal aging process.
  • provide new research resources, both through the incorporation of new research groups and cutting-edge infrastructure.

View our latest work

The immune system is based on a potential oncoprotein
  • The CSIC has discovered that the absence of the N-ras protein prevents differentiation of memory T lymphocytes
  • These cells are responsible for long term immunity and vaccine efficiency

Representative Publications

pdf flat small β-Arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism

pdf flat small Conformational changes in the T cell receptor differentially determine T cell subset development in mice

pdf flat small Global Metabolomic Profiling of Acute Myocarditis Caused by Trypanosoma cruzi Infection

pdf flat small Increased Nitric Oxide Bioavailability in Adult GRK2 Hemizygous Mice Protects Against Angiotensin II–Induced Hypertension

pdf flat small Pharmacological reversion of sphingomyelin‐induced dendritic spine anomalies in a Niemann Pick disease type A mouse model

pdf flat small DNA-guided DNA interference by a prokaryotic Argonaute

pdf flat small The need for transparency and good practices in the qPCR literature

pdf flat small High-resolution analysis of DNA synthesis start sites and nucleosome architecture at efficient mammalian replication origins

pdf flat small Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type

pdf flat small Analysis of the Dynamics of Infiltrating CD4+ T Cell Subsets in the Heart during Experimental Trypanosoma cruzi Infection

pdf flat small Function of oncogenes in cancer development: a changing paradigm

pdf flat small The transcriptome of Leishmania major in the axenic promastigote stage: transcript annotation and relative expression levels by RNA-seq

pdf flat small Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development

pdf flat small Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif

pdf flat small GSK-3β overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo

pdf flat small Ribonucleotides and manganese ions improve non-homologous end joining by human Polμ

pdf flat smallThe impact of quasispecies dynamics on the use of therapeutics

pdf flat small Gemin5 promotes IRES interaction and translation control through its C-terminal region

pdf flat small Evaluation of immune responses and analysis of the effect of vaccination of the Leishmania major recombinant ribosomal proteins L3 or L5 in two different murine models of cutaneous leishmaniasis

pdf flat small Differential Activity of Drosophila Hox Genes Induces Myosin Expression and Can Maintain Compartment Boundaries

pdf flat small Low hippocampal PI(4,5)P2 contributes to reduced cognition in old mice as a result of loss of MARCKS

pdf flat small Plasma Membrane Phosphatidylinositol 4,5 Bisphosphate Is Required for Internalization of Foot-and-Mouth Disease Virus and Vesicular Stomatitis Virus


Scientific Report


Nicolás Cabrera, 1, 28049 Madrid
Tel.: +34-911964401
Fax: +34-911964420
institucional at cbm.csic.es