Sunday, 18th February 2018
Special Seminar 22/02/2018
Alicia Hidalgo: Genetic mechanisms of structural plasticity and regeneration in the central nervous system
The CBMSO joins the celebration of International Women's and Girls' Day in Science. The CBMSO has a staff of 696 workers, of which 407 are women
La Academia de Ciencias premia a Margarita Salas con la Medalla Echegaray
Agreement between the Spanish Niemann Pick Foundation and the Severo Ochoa Foundation to support research on Niemann Pick disease in the group of Dr. Lola Ledesma
Convenio entre RedELA, Red de enfermos de esclerosis lateral amiotrófica (ELA), la Fundación Severo Ochoa y el grupo de investigación del Dr. Luis Carrasco para continuar con el estudio sobre la etiología de la ELA
Ginés Morata, Foreign Member of the Royal Society of London
Convenio de colaboración entre el Instituto de Investigación Sanitaria Fundación Jiménez Díaz y la Fundación Severo Ochoa para realizar el proyecto “Endocórnea 2”
An H2020-MSCA-Innovative Training Network for 10 PhD students with research projects aimed at improving immune receptor function for their use in immunotherapy against cancer (H2020-MSCA-ITN GA 721358)
European Training Network for cell-based Regenerative Medicine
CBMSO announces its participation in the European project METAFLUIDICS
Convenio de colaboración entre el CBMSO y la Fundación SEUR para promover el proyecto TAPONES PARA UNA NUEVA VIDA
Short videos
Answers to eight essential questions about our cells
Convenio de colaboración entre la Fundación Severo Ochoa y la Fundación Isabel Gemio para promover la investigación de enfermedades metabólicas hereditarias
Ultrahigh-throughput platform for the screening of thermostable proteins by thermophillic in vitro transcription-translation and microfluidics
A new human primase/polymerase with a potential impact in aging
Host Microbe Interactions in Health and Disease: Interface with the Immune System
Spanish cell therapy network



In the CBMSO we focus our research on the study of the molecular basis of human diseases with the ultimate goal of providing the necessary knowledge to design therapies, procedures and diagnostic methods that help improve the quality and life expectancy.

Our research in molecular biomedicine is based on two realities:

  • the need to reduce the social impact of the most disabling diseases.
  • the need to understand the molecular mechanisms of diseases to be able to translate them into biomedical applications.

Featured News

Brain-derived neurotrophic factor (BDNF) prevents neurodegeneration caused by frataxin deficiency
  • A study just published in the journal Molecular Therapy demonstrates that the neurotrophic factor BDNF is able to prevent the degeneration of neurons caused by frataxin deficiency (which is responsible for the development of Friedreich's ataxia)
  • Although it is a work of basic research with an animal model, this study suggests potential new avenues for therapeutic intervention into Friedreich's ataxia

Representative Publications

Recent Publications

pdf flat small L-arginine supplementation reduces mortality and improves disease outcome in mice infected with Trypanosoma cruzi

pdf flat small Genome Sequence of Trypanosoma cruzi Strain Bug2148

pdf flat small A Disulfide Bond in the Membrane Protein IgaA Is Essential for Repression of the RcsCDB System

pdf flat small A Specialized Peptidoglycan Synthase Promotes Salmonella Cell Division inside Host Cells

pdf flat small Phaeocystis globosa Virus DNA Polymerase X: a “Swiss Army knife”, Multifunctional DNA polymerase-lyase-ligase for Base Excision Repair

pdf flat small The anti/syn conformation of 8-oxo-7,8-dihydro-2′-deoxyguanosine is modulated by Bacillus subtilis PolX active site residues His255 and Asn263. Efficient processing of damaged 3′-ends

pdf flat small Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches

pdf flat small A bead-assisted flow cytometry method for the semi-quantitative analysis of Extracellular Vesicles

pdf flat small CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels

pdf flat small A multi-parametric analysis of Trypanosoma cruzi infection: common pathophysiologic patterns beyond extreme heterogeneity of host responses

pdf flat small T-Cell Intracellular Antigens and Hu Antigen R Antagonistically Modulate Mitochondrial Activity and Dynamics by Regulating Optic Atrophy 1 Gene Expression

pdf flat small Two-step ATP-driven opening of cohesin head

pdf flat small Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis

pdf flat small Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development

pdf flat small Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival

pdf flat small Human PrimPol activity is enhanced by RPA

pdf flat small Mutualism supports biodiversity when the direct competition is weak

pdf flat small Discovery of a new family of relaxases in Firmicutes bacteria

pdf flat small N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes

pdf flat small Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection

pdf flat small PLD3 gene and processing of APP

pdf flat small Perspectives on Intra- and Intercellular Trafficking of Hedgehog for Tissue Patterning

pdf flat small Characterization of two distinct early post-entry blocks to HIV-1 in common marmoset lymphocytes

pdf flat small Fungal Enolase, β-Tubulin, and Chitin Are Detected in Brain Tissue from Alzheimer’s Disease Patients

pdf flat small G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis

pdf flat small Effective competition determines the global stability of model ecosystems

pdf flat small Genomic cartography and proposal of nomenclature for the repeated, interspersed elements of the Leishmania major SIDER2 family and identification of SIDER2-containing transcripts

pdf flat small Learning structural bioinformatics and evolution with a snake puzzle

pdf flat small TruePrime is a novel method for whole-genome amplification from single cells based on TthPrimPol


Discover our groups

Mitochondrial pathophysiology


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