Monday, 3rd August 2015
Hedgehog Signaling in Development, Tissue repair and Cancer
October 21-25, 2015, Puerto Varas, Chile
Tribute to Alfredo Villasante
Consolider BrainAge 2010
Brain dysfunction during aging
Aims to explore question is whether developmental mechanisms can help to maintain adult organ homeostasis and their relationship with disease
Ultrahigh-throughput platform for the screening of thermostable proteins by thermophillic in vitro transcription-translation and microfluidics
La mitocondria y su implicación en patología humana
A new human primase/polymerase with a potential impact in aging
Redes moleculares y celulares en enfermedades inflamatorias
Host Microbe Interactions in Health and Disease: Interface with the Immune System
Study of cellular and molecular mediators of fibrogenesis
European Consortium for Development of Stem Cell-Based Therapy for Thymic Regeneration
The study of the biology of neural stem cells for its use in cell therapy of neurodegenerative diseases
Spanish cell therapy network



At the CBMSO we canalize our research to understand the molecular basis of human pathologies in particular of age-related diseases, most prevalent in our society, with the final aim to provide the necessary knowledge for the design of efficient therapies that help improve overall health and life expectancy.

Our strategic lines are based on two realities:

  • a societal need to reduce the impact of the most invalidating diseases,
  • the current involvement of the CBMSO in the study of the molecular mechanisms of pathologies with increased incidence in the aged.


Taking advantage of our current workforce, the CBMSO strategic plan aims at improving the efficiency of our research and its outreach by nucleating the Center´s research focus on the molecular basis of human diseases with special emphasis on those pathologies associated with age including brain degenerative disorders, immune and inflammatory components of different diseases, and disturbances in the control of cell proliferation and differentiation.


  • strengthen interactions between the basic research teams at the CBMSO and clinical researchers working in associated clinical institutes and hospitals.
  • disseminate information about the causes and underlying molecular mechanisms of age-related diseases and advances in pathological aging research to the general public, health care professionals and the scientific community.
  • boost already exiting intramural interactions between genetic, structural, biological and behavioural approaches to research on the molecular basis of disease and disease-associated events that disturb the normal aging process.
  • provide new research resources, both through the incorporation of new research groups and cutting-edge infrastructure.

View our latest work

César Cobaleda, galardonado con El Premio Feder 2015, en la modalidad 'Premio a la investigación en enfermedades raras'
  • Premio a la Investigación en Enfermedades Raras al Grupo de Investigación del Dr. Cesar Cobaleda en el Centro de Biología Molecular Severo Ochoa (CBMSO), por su investigación centrada en el estudio de la plasticidad celular estudiando los mecanismos moleculares que participan en la patología del Síndrome de Wolf-Hirschhorn (SWH)

Representative Publications

pdf flat small Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs

pdf flat small Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis

pdf flat small LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery

pdf flat small A Pathogenetic Role for Endothelin-1 in Peritoneal Dialysis-Associated Fibrosis

pdf flat small Secreted Herpes Simplex Virus-2 Glycoprotein G Modifies NGF-TrkA Signaling to Attract Free Nerve Endings to the Site of Infection

pdf flat small Dissecting the role of the ϕ29 terminal protein DNA binding residues in viral DNA replication

pdf flat small Secreted Frizzled Related Proteins Modulate Pathfinding and Fasciculation of Mouse Retina Ganglion Cell Axons by Direct and Indirect Mechanisms

pdf flat small Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization

pdf flat small Initiation codon selection is accomplished by a scanning mechanism without crucial initiation factors in Sindbis virus subgenomic mRNA

pdf flat small Dominant Role of the ERAP1 Polymorphism R528K in Shaping the HLA–B27 Peptidome Through Differential Processing Determined by Multiple Peptide Residues

Recent Publications

pdf flat small T-cell intracellular antigens in health and disease

pdf flat small Multifunctionality of a Picornavirus Polymerase Domain: Nuclear Localization Signal and Nucleotide Recognition

pdf flat small The Mammalian Cell Cycle Regulates Parvovirus Nuclear Capsid Assembly

pdf flat small Biodiversity and distribution of polar freshwater DNA viruses

pdf flat small Chromatin and development: a special issue


Scientific Report


Nicolás Cabrera, 1, 28049 Madrid
Tel.: +34-911964401
Fax: +34-911964420
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